| Player |
|
Status/Updated |
Notes |
| Siran Neal
|
DB |
Ques Sept. 21 - Concussion - 9/16/25 |
Neal is dealing with a concussion, and it is up in the air if he will suit up against the Cardinals on September 21st. |
| Spencer Burford
|
OL |
Ques Sept 21 - Knee - 9/16/25 |
Burford is battling a knee injury, and it is up in the air if he will suit up against the Cardinals on September 21st. |
| Jauan Jennings
|
WR |
Ques Sept. 21 - Ankle - 9/15/25 |
Jennings is bothered by an ankle injury, and it is unclear if he will face Cardinals on September 21st. |
| Kyle Juszczyk
|
FB |
Ques Sept. 21 - Concussion - 9/14/25 |
Juszczyk left the match due to a concussion, and it is uncertain if he will face Cardinals on September 21st. |
| Trent Williams
|
OT |
Ques Sept. 21 - Knee - 9/14/25 |
Williams is dealing with a knee injury, and it is uncertain if he will face Cardinals on September 21st. |
| Dominick Puni
|
OL |
Ques Sept. 21 - Knee - 9/14/25 |
Puni is battling an knee injury, and it is uncertain if he will face Cardinals on September 21st. |
| C.J. West
|
DT |
Ques Sept. 21 - Knee - 9/14/25 |
West is nursing with a knee injury, and it is unclear if he will face Cardinals on September 21st. |
| Nick Martin
|
LB |
Ques Sept. 21 - Lower Body - 9/14/25 |
Martin is hampered by a lower body injury, and it is uncertain if he will face Cardinals on September 21st. |
| Jordan Watkins
|
WR |
Ques Sept. 21 - Ankle - 9/14/25 |
Watkins is nursing with an ankle injury, and it is unknown if he will face Cardinals on September 21st. |
| Jordan James
|
RB |
Ques Sept. 21 - Knee - 9/14/25 |
James is hampered by a knee injury, and it is uncertain if he will face Cardinals on September 21st. |
| Brock Purdy
|
QB |
Out indefinitely - Toe - 9/11/25 |
Purdy is laid up with a turf toe injury, and is expected to miss anywhere between the next two-five weeks. |
| Ben Bartch
|
OL |
Out Sept 21 - Ankle - 9/17/25 |
Bartch is bothered by an ankle injury, and he is not projected to dress against the Cardinals on September 21st. |
| George Kittle
|
TE |
Early Oct - Hamstring - 9/9/25 |
Kittle has hit the injured reserve list due to a hamstring injury, and he is projected to miss the upcoming four games. |
| Ameer Abdullah
|
RB |
out for season - Ribs - 8/27/25 |
Abdullah has been placed on the season ending injured reserve due to a ribs injury. |
| Equanimeous St. Brown
|
WR |
out for season - Foot - 8/27/25 |
St. Brown has been placed on the season ending injured reserve due to a foot injury. |
| Jakob Robinson
|
CB |
out for season - Forearm - 8/28/25 |
Robinson is placed on the injured reserve list with a forearm injury, and he is projected to miss the remainder of the season. |
| Patrick Taylor Jr.
|
RB |
out for season - Shoulder - 8/20/25 |
Taylor Jr. has been added to the injured reserve list after he underwent season-ending surgery to repair a fracture in his shoulder, and has been shut down for the remainder of the season. |
| Tarron Jackson
|
DL |
Out indefinitely - Undisclosed - 7/29/25 |
Jackson is dealing with an undisclosed injury, and it is unclear how long he will be idle. |
| Jacob Cowing
|
WR |
Out Indefinitely - Leg - 8/28/25 |
Cowing has been designated for the injured reserve list due to a leg injury, and he will miss an undetermined length of time. |
| Malik Mustapha
|
S |
Out indefinitely - Knee - 8/28/25 |
Mustapha has landed on the PUP list while recovering from a torn acl, and a timetable for return has yet to be established. |
| Brandon Aiyuk
|
WR |
Out indefinitely - Knee - 8/28/25 |
Aiyuk is on the PUP list while recovering from knee surgery, and he will miss an extended period. |
| Kurtis Rourke
|
QB |
Out indefinitely - Knee - 8/28/25 |
Rourke has been shuttled to the NFI list with a knee injury, and he will miss an undetermined length of time. |
| Kevin Givens
|
DT |
Out indefinitely - Pectoral - 8/28/25 |
Givens is placed on the injured reserve list with a pectoral injury, and he will miss an extended period. |
| Trent Taylor
|
WR |
Out indefinitely - Undisclosed - 7/25/25 |
Taylor has been put on the injured reserve list with an undisclosed injury, and he is projected to miss the remainder of the season. |
| Tre Tomlinson
|
CB |
Out indefinitely - Undisclosed - 7/25/25 |
Tomlinson is on the injured reserve list due to an undisclosed injury, and is expected to be sidelined for the entire season. |